Think about your setting. Settings. If you can pull off the mismatch, and launch a successful tempest in a teapot, I shall cheer you on. But avoid the common error of trying to make a story seem larger and more important by inflating the settings. This is a mistake made in science fiction and fantasy all the time. If you need to spring a prisoner from the federal pen, there is no reason to locate that prison on the Moon. Trust me, there really isn't.
I'm still trying to find a story to fit Kauai. It's small, but it carries the risk that almost everyone out there has an idea of what Hawaii is. Anything I can say will be familiar but not a match to a reader's understanding. It's too unique. And heck, it's cute. It's a lovely place with lovely people. When I first moved here the police blotter included loose cow reports, and who am I to comment on the moral turpitude of farm animals?